Article
Transmission/disequilibrium test meets measured haplotype analysis: family-based association analysis guided by evolution of haplotypes.
American journal of human genetics - 1 May 2001
Seltman H, Roeder K, Devlin B
Abstract excerpt
Family data teamed with the transmission/disequilibrium test (TDT), which simultaneously evaluates linkage and association, is a powerful means of detecting disease-liability alleles. To increase the information provided by the test, various researchers have proposed TDT-based methods for haplotype transmission. Haplotypes indeed produce more-definitive transmissions than do the alleles comprising them, and this...
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