Article
X-rays induce distinct patterns of somatic mutation in fetal versus adult hematopoietic cells.
DNA repair - 1 Sept 2007
Liang Li, Deng Li, Mendonca Marc S, Chen Yanping, Zheng Betty, Stambrook Peter J, Shao Changshun, Tischfield Jay A
Abstract excerpt
There are a variety of mechanisms and pathways whereby cells safeguard their genomes in the face of environmental insults that damage DNA. Whether each of these pathways is equally robust at specific developmental stages in mammals and whether they are also modulated in a tissue-specific manner, however, are unclear. Here, we report that ionizing radiation (IR) produces different types of somatic mutations in...
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