Article
Structural basis for selectivity and toxicity of ribosomal antibiotics.
EMBO reports - 1 Apr 2001
Böttger E C, Springer B, Prammananan T, Kidan Y, Sander P
Abstract excerpt
Ribosomal antibiotics must discriminate between bacterial and eukaryotic ribosomes to various extents. Despite major differences in bacterial and eukaryotic ribosome structure, a single nucleotide or amino acid determines the selectivity of drugs affecting protein synthesis. Analysis of resistance mutations in bacteria allows the prediction of whether cytoplasmic or mitochondrial ribosomes in eukaryotic cells...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.