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A novel pleuromutilin antibacterial compound, its binding mode and selectivity mechanism

13 Dec 2016

Abstract excerpt

The increasing appearance of pathogenic bacteria with antibiotic resistance is a global threat. Consequently, clinically available potent antibiotics that are active against multidrug resistant pathogens are becoming exceedingly scarce. Ribosomes are a main target for antibiotics, and hence are an objective for novel drug development. Lefamulin, a semi-synthetic pleuromutilin compound highly active against...

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PMID: 27958389
DOI: 10.1038/srep39004

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