Article
Development and characterization of breast carcinoma cell lines as in vitro and in vivo models for breast cancer diagnosis and therapy.
In vitro cellular & developmental biology : journal of the Tissue Culture Association - 1 Jun 1992
Ceriani R L, Peterson J A, Blank E W, Chan C M, Cailleau R
Abstract excerpt
To establish a model system for preclinical radioimmunotherapy studies, attempts were made to graft 16 different human breast carcinoma cell lines into BALB/c nu/nu(nude) mice. Nine produced serially transplantable tumors growing at a variable rate, whereas seven failed to do so. Conversely, three new cell lines were established in monolayer culture from transplantable human breast tumors in nude mice. Twelve...
Topics
- Animals
- Breast Neoplasms
- DNA, Neoplasm
- Disease Models, Animal
- Female
- Flow Cytometry
- Genotype
- Humans
- Immunohistochemistry
- Mammary Neoplasms, Experimental