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Article

Amino acid usage is asymmetrically biased in AT- and GC-rich microbial genomes.

PloS one - 1 Jan 2013

Bohlin Jon, Brynildsrud Ola, Vesth Tammi, Skjerve Eystein, Ussery David W

Abstract excerpt

INTRODUCTION: Genomic base composition ranges from less than 25% AT to more than 85% AT in prokaryotes. Since only a small fraction of prokaryotic genomes is not protein coding even a minor change in genomic base composition will induce profound protein changes. We examined how amino acid and codon frequencies were distributed in over 2000 microbial genomes and how these distributions were affected by base...

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PMID: 23922837
DOI: 10.1371/journal.pone.0069878
PMCID: PMC3724673

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