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Article

Generation and characterization of cells that can be conditionally depleted of mitochondrial SOD2.

Biochemical and biophysical research communications - 6 Feb 2009

Takada Shunya, Inoue Eri, Tano Keizo, Yoshii Hanako, Abe Takuya, Yoshimura Akari, Akita Motomu, Tada Shusuke, Watanabe Masami, Seki Masayuki, Enomoto Takemi

Abstract excerpt

Manganese-dependent superoxide dismutase (SOD2) serves as the primary defense against mitochondrial superoxide, and decreased SOD2 activity results in a range of pathologies. To investigate the events occurring soon after depletion of SOD2, we generated SOD2 gene knockout chicken DT40 cells complemented with a human SOD2 (hSOD2) cDNA, whose expression can be switched off by doxycycline (Dox). When SOD2 was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19100713
DOI: 10.1016/j.bbrc.2008.12.031

Genes

SOD2

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