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Article

p53 Mutations and microsatellite instability in ovarian cancer: Yin and yang.

American journal of obstetrics and gynecology - 1 Apr 2001

Buller R E, Shahin M S, Holmes R W, Hatterman M, Kirby P A, Sood A K

Abstract excerpt

OBJECTIVE: We tested the hypothesis that p53 frameshift mutations in ovarian cancer occur as a result of genomic instability rather than as a proximal cause of this process. STUDY DESIGN: Sequencing of the p53 tumor suppressor gene has been carried out on 305 ovarian, fallopian tube, and peritoneal cancers. Two groups of p53 null mutations were identified: (1) those caused by frameshift insertion or deletion...

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Share to DNA, Neoplasm
Share to Electrophoresis, Agar Gel
Share to Frameshift Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, p53

Share to Microsatellite Repeats

Share to Ovarian Neoplasms

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to RNA, Neoplasm

Source

Identifiers

PMID: 11303196
DOI: 10.1067/mob.2001.113856

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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