Article
In vivo inhibition of endogenous brain tumors through systemic interference of Hedgehog signaling in mice.
Mechanisms of development - 1 Feb 2005
Sanchez Pilar, Ruiz i Altaba Ariel
Abstract excerpt
The full spectrum of developmental potential includes normal as well as abnormal and disease states. We therefore subscribe to the idea that tumors derive from the operation of paradevelopmental programs that yield consistent and recognizable morphologies. Work in frogs and mice shows that Hedgehog (Hh)-Gli signaling controls stem cell lineages and that its deregulation leads to tumor formation. Moreover, human...
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