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Glioma tropism of lentivirally transduced hematopoietic progenitor cells

21 Apr 2010

Abstract excerpt

Experimental gliomas attract hematopoietic progenitor cells (HPC) in vivo. HPC are therefore promising candidates for a cell-based delivery of therapeutic molecules to experimental gliomas. A therapeutic application requires efficient genetic manipulation of the cellular vector and a lack of tumorigenicity. Here, we studied the impact of lenti-viral transduction on the glioma tropism of human or murine HPC....

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PMID: 20428764
DOI: 10.3892/ijo_00000626

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