Article
Plasmodium falciparum: sequence diversity and antibody recognition of the Merozoite surface protein-2 (MSP-2) in Brazilian Amazonia.
Experimental parasitology - 1 Jan 2000
Tonon Angela Pedroso, Hoffmann Erika Hellena Esther, Silveira Lucimeire Antonelli da, Ribeiro Adálton Guimarães, Gonçalves Clara Rosa da Silva, Ribolla Paulo Eduardo Martins, Wunderlich Gerhard, Ferreira Marcelo Urbano
Abstract excerpt
The merozoite surface protein-2 (MSP-2) of Plasmodium falciparum comprises repeats flanked by dimorphic domains defining the allelic families FC27 and IC1. Here, we examined sequence diversity at the msp-2 locus in Brazil and its impact on MSP-2 antibody recognition by local patients. Only 25 unique partial sequences of msp-2 were found in 61 isolates examined. The finding of identical msp-2 sequences in...
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