Article
Molecular structure of eight human autoreactive monoclonal antibodies.
Immunology - 1 Mar 2001
Aguilera I, Melero J, Nuñez-Roldan A, Sanchez B
Abstract excerpt
The heavy (H) and light (L) chain V-region sequences of eight human autoreactive immunoglobulin M (IgM) monoclonal antibodies (mAbs: BY-4, BY-7, BY-12, IRM-3, IRM-7, IRM-8, IRM-10 and CDC-1) were determined at the cDNA level. All VH and VL families were identified. Four different VH families were represented, VH3 being the most common as five of the mAbs (BY-7, BY-12, IRM-3, IRM-8 and CDC-1) used genetic elements...
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