Article
A basic residue at position 36p of the propeptide is not essential for the correct folding and subsequent autocatalytic activation of prochymosin.
European journal of biochemistry - 1 Apr 2001
Francky A, Francky B M, Strukelj B, Gruden K, Ritonja A, Krizaj I, Kregar I, Pain R H, Pungercar J
Abstract excerpt
Position 36p in the propeptides of gastric aspartic proteinases is generally occupied by lysine or arginine. This has led to the conclusion that a basic residue at this position, which interacts with the active-site aspartates, is essential for folding and activation of the zymogen. Lamb prochymo...
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