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Article

N-terminal portion acts as an initiator of the inactivation of pepsin at neutral pH.

Protein engineering - 1 Sept 2001

Tanaka T, Yada R Y

Abstract excerpt

Porcine pepsin, an aspartic protease, is unstable at neutral pHs where it rapidly loses activity, however, its zymogen, pepsinogen, is stable at neutral pHs. The difference between the two is the presence of the prosegment in pepsinogen. In this study, possible factors responsible for instability were investigated and included: (i) the distribution of positively charged residues on the surface, (ii) an insertion...

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Identifiers

PMID: 11707613
DOI: 10.1093/protein/14.9.669

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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