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Article

Conserved prosegment residues stabilize a late-stage folding transition state of pepsin independently of ground states.

PloS one - 1 Jan 2014

Dee Derek R, Horimoto Yasumi, Yada Rickey Y

Abstract excerpt

The native folding of certain zymogen-derived enzymes is completely dependent upon a prosegment domain to stabilize the folding transition state, thereby catalyzing the folding reaction. Generally little is known about how the prosegment accomplishes this task. It was previously shown that the prosegment catalyzes a late-stage folding transition between a stable misfolded state and the native state of pepsin. In...

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Identifiers

PMID: 24983988
DOI: 10.1371/journal.pone.0101339
PMCID: PMC4077824

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Source receipt: pubmed, retrieved 7 Sept 2026.

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