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Article

A defect in bone marrow derived dendritic cell maturation in the nonobesediabetic mouse.

Clinical and experimental immunology - 1 Mar 2001

Strid J, Lopes L, Marcinkiewicz J, Petrovska L, Nowak B, Chain B M, Lund T

Abstract excerpt

The pathogenesis of diabetes in the nonobese diabetic (NOD) mouse is characterized by a selective destruction of the insulin-producing beta-cells in the islets of Langerhans mediated by autoreactive T cells. The function of T cells is controlled by dendritic cells (DC), which are not only the most potent activators of naïve T cells, but also contribute significantly to the establishment of central and peripheral...

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Source

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Identifiers

PMID: 11298122
DOI: 10.1046/j.1365-2249.2001.01473.x
PMCID: PMC1906008

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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