Article
Dipeptidyl peptidase-IV inhibits glioma cell growth independent of its enzymatic activity.
The international journal of biochemistry & cell biology - 1 May 2012
Busek Petr, Stremenova Jarmila, Sromova Lucie, Hilser Marek, Balaziova Eva, Kosek Dalibor, Trylcova Jana, Strnad Hynek, Krepela Evzen, Sedo Aleksi
Abstract excerpt
Malignant gliomas exhibit abnormal expression of proteolytic enzymes that may participate in the uncontrolled cell proliferation and aberrant interactions with the brain extracellular matrix. The multifunctional membrane bound serine aminopeptidase dipeptidyl peptidase (DPP)-IV has been linked to the development and progression of several malignancies, possibly both through the enzymatic and nonenzymatic...
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