Article
Allelic association with SNPs: metrics, populations, and the linkage disequilibrium map.
Human mutation - 1 Apr 2001
Collins A, Ennis S, Taillon-Miller P, Kwok P Y, Morton N E
Abstract excerpt
Comparison of different metrics, using three large samples of haplotypes from different populations, demonstrates that rho is the most efficient measure of association between pairs of single nucleotide polymorphisms (SNPs). Pairwise data can be modeled, using composite likelihood, to describe the decline in linkage disequilibrium with distance (the Malecot model). The evidence from more isolated populations...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.