Article
The estimator of the optimal measure of allelic association: mean, variance and probability distribution when the sample size tends to infinity.
Statistical applications in genetics and molecular biology - 1 Jan 2008
Mangin Brigitte, Garnier-Géré Pauline, Cierco-Ayrolles Christine
Abstract excerpt
The allelic association or linkage disequilibrium between two loci is a parameter of fundamental interest in modern population genetics for evolutionary inference and association mapping studies. Among the many measures available, the optimal measure of allelic association rho presents a strong evolutionary theory basis and is modeled on the physical distance along the chromosome with the Malécot equation for...
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