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Article

High affinity T cell receptors from yeast display libraries block T cell activation by superantigens.

Journal of molecular biology - 13 Apr 2001

Kieke M C, Sundberg E, Shusta E V, Mariuzza R A, Wittrup K D, Kranz D M

Abstract excerpt

The alphabeta T cell receptor (TCR) can be triggered by a class of ligands called superantigens. Enterotoxins secreted by bacteria act as superantigens by simultaneously binding to an MHC class II molecule on an antigen- presenting cell and to a TCR beta-chain, thereby causing activation of the T cell. The cross-reactivity of enterotoxins with different Vbeta regions can lead to stimulation of a large fraction of...

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Identifiers

PMID: 11292343
DOI: 10.1006/jmbi.2001.4560

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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