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Article

Gremlin negatively modulates BMP-4 induction of embryonic mouse lung branching morphogenesis

1 May 2001

Abstract excerpt

Bone morphogenetic protein-4 (BMP-4) is a key morphogen for embryonic lung development that is expressed at high levels in the peripheral epithelium, but the mechanisms that modulate BMP-4 function in early mouse lung branching morphogenesis are unclear. Here, we studied the BMP-4 antagonist Gremlin, which is a member of the DAN family of BMP antagonists that can bind and block BMP-2/4 activity. The expression...

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Identifiers

PMID: 11290528
DOI: 10.1152/ajplung.2001.280.5.l1030

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