Article
Modulation of a transcription factor counteracts heterochromatic gene silencing in Drosophila.
Cell - 23 Mar 2001
Ahmad K, Henikoff S
Abstract excerpt
Variegation is a common feature of gene silencing phenomena, yet the basis for stochastic on/off expression is unknown. We used a conditional system that allows probing of heterochromatin at a reporter GFP gene by altering GAL4 transcription factor levels during Drosophila eye development. Surprisingly, the frequency of gene silencing is exquisitely sensitive to GAL4 levels, as though binding site occupancy...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.