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Article

Position effect variegation (PEV) as an aging clock: visualization of age-dependent loss of heterochromatin and longevity associated with enhanced heterochromatin.

Scientific reports - 8 Jan 2026

Tedeschi Sesley, Takahashi Talia, Vyavahare Yash, Clark Emma, Deutschmann Logan, Leung Raynord, Stanley Kat, Hunt Liam C

Abstract excerpt

The heterochromatin loss model of aging suggests there is an age-dependent reduction in epigenetic factors that form and maintain the heterochromatin state of chromosomes. Position Effect Variegation (PEV) can visually report phenotypes of heterochromatin mediated silencing in Drosophila Melanogaster eyes and we use PEV to examine the association between heterochromatin state changes and aging. Pericentric...

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Identifiers

PMID: 41507356
DOI: 10.1038/s41598-025-34978-1
PMCID: PMC12868830

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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