Article
Fit genotypes and escape variants of subgroup III Neisseria meningitidis during three pandemics of epidemic meningitis.
Proceedings of the National Academy of Sciences of the United States of America - 24 Apr 2001
Zhu P, van der Ende A, Falush D, Brieske N, Morelli G, Linz B, Popovic T, Schuurman I G, Adegbola R A, Zurth K, Gagneux S, Platonov A E, Riou J Y, Caugant D A, Nicolas P, Achtman M
Abstract excerpt
The genetic variability at six polymorphic loci was examined within a global collection of 502 isolates of subgroup III, serogroup A Neisseria meningitidis. Nine "genoclouds" were identified, consisting of genotypes that were isolated repeatedly plus 48 descendent genotypes that were isolated rarely. These genoclouds have caused three pandemic waves of disease since the mid-1960s, the most recent of which was...
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