Article
Genetic diversification of Neisseria meningitidis during waves of colonization and disease in the meningitis belt of sub-Saharan Africa.
Vaccine - 3 Sept 2007
Leimkugel Julia, Forgor Abudulai Adams, Dangy Jean-Pierre, Pflüger Valentin, Gagneux Sebastien, Hodgson Abraham, Pluschke Gerd
Abstract excerpt
Although Neisseria meningitidis is a highly variable organism, most invasive disease is caused by a minority of genotypes. Hypervirulent lineages have been identified and their pandemic spread has been traced. During a longitudinal meningococcal colonization study in a district of northern Ghana clonal waves of carriage and disease were observed. Genetic diversification of genoclouds was analysed by pulsed field...
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