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Article

Loss of Genomic Diversity in a Neisseria meningitidis Clone Through a Colonization Bottleneck.

Genome biology and evolution - 1 Aug 2018

Lamelas Araceli, Hamid Abdul-Wahab M, Dangy Jean-Pierre, Hauser Julia, Jud Maja, Röltgen Katharina, Hodgson Abraham, Junghanss Thomas, Harris Simon R, Parkhill Julian, Bentley Stephen D, Pluschke Gerd

Abstract excerpt

Neisseria meningitidis is the leading cause of epidemic meningitis in the "meningitis belt" of Africa, where clonal waves of colonization and disease are observed. Point mutations and horizontal gene exchange lead to constant diversification of meningococcal populations during clonal spread. Maintaining a high genomic diversity may be an evolutionary strategy of meningococci that increases chances of fixing...

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PMID: 30060167
DOI: 10.1093/gbe/evy152
PMCID: PMC6110524

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