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Article

Large scale genomic analysis shows no evidence for pathogen adaptation between the blood and cerebrospinal fluid niches during bacterial meningitis.

Microbial genomics - 1 Jan 2017

Lees John A, Kremer Philip H C, Manso Ana S, Croucher Nicholas J, Ferwerda Bart, Serón Mercedes Valls, Oggioni Marco R, Parkhill Julian, Brouwer Matthijs C, van der Ende Arie, van de Beek Diederik, Bentley Stephen D

Abstract excerpt

Recent studies have provided evidence for rapid pathogen genome diversification, some of which could potentially affect the course of disease. We have previously described such variation seen between isolates infecting the blood and cerebrospinal fluid (CSF) of a single patient during a case of bacterial meningitis. Here, we performed whole-genome sequencing of paired isolates from the blood and CSF of 869...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28348877
DOI: 10.1099/mgen.0.000103
PMCID: PMC5361624

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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