Article
Role of selection in the emergence of lineages and the evolution of virulence in Neisseria meningitidis.
Proceedings of the National Academy of Sciences of the United States of America - 30 Sept 2008
Buckee Caroline O, Jolley Keith A, Recker Mario, Penman Bridget, Kriz Paula, Gupta Sunetra, Maiden Martin C J
Abstract excerpt
Neisseria meningitis is a human commensal bacterium that occasionally causes life-threatening disease. As with a number of other bacterial pathogens, meningococcal populations comprise distinct lineages, which persist over many decades and during global spread in the face of high rates of recombination. In addition, the propensity to cause invasive disease is associated with particular "hyperinvasive" lineages...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Child
- Child, Preschool
- Czech Republic
- Evolution, Molecular
- Female
- Genetic Variation
- Humans
- Infant
- Male