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Article

Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung.

Developmental biology - 1 Nov 2006

De Langhe Stijn P, Carraro Gianni, Warburton David, Hajihosseini Mohammad K, Bellusci Saverio

Abstract excerpt

Fibroblast growth factor (FGF) signaling has been shown to regulate lung epithelial development but its influence on mesenchymal differentiation has been poorly investigated. To study the role of mesenchymal FGF signaling in the differentiation of the mesenchyme and its impact on epithelial morphogenesis, we took advantage of Fgfr2c(+/Delta) mice, which due to a splicing switch express Fgfr2b in mesenchymal...

Topics

Animals
Animals, Newborn
Autocrine Communication
Cell Differentiation
Epithelial Cells
Fibroblast Growth Factor 10
Fibronectins
Gene Expression Regulation, Developmental
Heterozygote
Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mesoderm

Mice

Myocytes, Smooth Muscle

Phenotype

RNA, Messenger

Receptor, Fibroblast Growth Factor, Type 2

Signal Transduction

Stem Cells

Source

Identifiers

PMID: 16989802
DOI: 10.1016/j.ydbio.2006.07.001

Genes

FGF10
FGFR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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