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Article

dRecQ4 Is Required for DNA Synthesis and Essential for Cell Proliferation in Drosophila

1 Jul 2009

Abstract excerpt

BACKGROUND: The family of RecQ DNA helicases plays an important role in the maintenance of genomic integrity. Mutations in three of the five known RecQ family members in humans, BLM, WRN and RecQ4, lead to disorders that are characterized by predisposition to cancer and premature aging. METHODOLOGY/PRINCIPAL FINDINGS: To address the in vivo functions of Drosophila RecQ4 (dRecQ4), we generated mutant alleles of...

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PMID: 19572017
DOI: 10.1371/journal.pone.0006107

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