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Article

Identification of human p53 mutations with differential effects on the bax and p21 promoters using functional assays in yeast.

Oncogene - 12 Mar 1998

Flaman J M, Robert V, Lenglet S, Moreau V, Iggo R, Frebourg T

Abstract excerpt

Recent studies have suggested that a rare class of p53 mutants found in tumours has a subtle transcriptional defect affecting bax induction but not p21 induction. We have therefore developed simple functional assays in yeast which can be used to identify these mutants. Analysis of 51 different mutations observed in human tumours showed that all mutants tested scored as mutant with the bax reporter strain but nine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Promoter Regions, Genetic

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Source

Identifiers

PMID: 9546439
DOI: 10.1038/sj.onc.1201889

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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