Article
Reduction of the amyloidogenicity of a protein by specific binding of ligands to the native conformation.
Protein science : a publication of the Protein Society - 1 Apr 2001
Chiti F, Taddei N, Stefani M, Dobson C M, Ramponi G
Abstract excerpt
It is known that human muscle acylphosphatase (AcP) is able, under appropriate conditions in vitro, to aggregate and form amyloid fibrils of the type associated with human diseases. A number of compounds were tested for their ability to bind specifically to the native conformation of AcP under conditions favoring denaturation and subsequent aggregation and fibril formation. Compounds displaying different binding...
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