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Article

Studies of the aggregation of mutant proteins in vitro provide insights into the genetics of amyloid diseases.

Proceedings of the National Academy of Sciences of the United States of America - 10 Dec 2002

Chiti Fabrizio, Calamai Martino, Taddei Niccolo, Stefani Massimo, Ramponi Giampietro, Dobson Christopher M

Abstract excerpt

Protein aggregation and the formation of highly insoluble amyloid structures is associated with a range of debilitating human conditions, which include Alzheimer's disease, Parkinson's disease, and the Creutzfeldt-Jakob disease. Muscle acylphosphatase (AcP) has already provided significant insigh...

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Identifiers

PMID: 12374855
DOI: 10.1073/pnas.212527999
PMCID: PMC139903

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12374855-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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