Article
Molecular mechanisms of fibrillogenesis and the protective role of amyloid P component: two possible avenues for therapy.
Ciba Foundation symposium - 1 Jan 1996
Pepys M B, Tennent G A, Booth D R, Bellotti V, Lovat L B, Tan S Y, Persey M R, Hutchinson W L, Booth S E, Madhoo S, Soutar A K, Hawkins P N, Van Zyl-Smit R, Campistol J M, Fraser P E, Radford S E, Robinson C V, Sunde M, Serpell L C, Blake C C
Abstract excerpt
Amyloid deposits regress when the supply of fibril precursor proteins is sufficiently reduced, indicating that amyloid fibrils are degradable in vivo. Serum amyloid P component (SAP), a universal constituent of amyloid deposits, efficiently protects amyloid fibrils from proteolysis in vitro, and may contribute to persistence of amyloid in vivo. Drugs that prevent binding of SAP to amyloid fibrils in vivo should...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.