Article
An SH2-domain-containing kinase negatively regulates the phosphatidylinositol-3 kinase pathway.
Genes & development - 15 Mar 2001
Moniakis J, Funamoto S, Fukuzawa M, Meisenhelder J, Araki T, Abe T, Meili R, Hunter T, Williams J, Firtel R A
Abstract excerpt
SHK1 is a novel dual-specificity kinase that contains an SH2 domain in its C-terminal region. We demonstrate that SHK1 is required for proper chemotaxis and phagocytosis. Mutant shk1 null cells lack polarity, move very slowly, and exhibit an elevated and temporally extended chemoattractant-mediated activation of the kinase Akt/PKB. GFP fusions of the PH domain of Akt/PKB or the PH-domain-containing protein CRAC,...
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