Article
Loss of SMEK, a novel, conserved protein, suppresses MEK1 null cell polarity, chemotaxis, and gene expression defects.
Molecular and cellular biology - 1 Sept 2005
Mendoza Michelle C, Du Fei, Iranfar Negin, Tang Nan, Ma Hui, Loomis William F, Firtel Richard A
Abstract excerpt
MEK/extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase signaling is imperative for proper chemotaxis. Dictyostelium mek1(-) (MEK1 null) and erk1(-) cells exhibit severe defects in cell polarization and directional movement, but the molecules responsible for the mek1(-) and erk1(-) chemotaxis defects are unknown. Here, we describe a novel, evolutionarily conserved gene and protein (smkA...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.