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Article

Roles of cell-cell adhesion-dependent tyrosine phosphorylation of Gab-1.

The Journal of biological chemistry - 1 Jun 2001

Shinohara M, Kodama A, Matozaki T, Fukuhara A, Tachibana K, Nakanishi H, Takai Y

Abstract excerpt

Gab-1 is a multiple docking protein that is tyrosine phosphorylated by receptor tyrosine kinases such as c-Met, hepatocyte growth factor/scatter factor receptor, and epidermal growth factor receptor. We have now demonstrated that cell-cell adhesion also induces marked tyrosine phosphorylation of Gab-1 and that disruption of cell-cell adhesion results in its dephosphorylation. An anti-E-cadherin antibody decreased...

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Identifiers

PMID: 11262408
DOI: 10.1074/jbc.M100909200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Roles of cell-cell adhesion-dependent tyrosine phosphorylation of Gab-1.PMID 11262408Read ↗

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Participation of both Gab1 and Gab2 in the activation of the ERK/MAPK pathway by epidermal growth factor.Semantic proximity Read ↗

Src phosphorylates Grb2-associated binder 1 upon hepatocyte growth factor stimulation.Semantic proximity Read ↗

Gab1 is required for EGF receptor signaling and the transformation by activated ErbB2.Semantic proximity Read ↗

Distinct requirements for Gab1 in Met and EGF receptor signaling <i>in vivo</i>Semantic proximity Read ↗

The adaptor protein Gab1 couples the stimulation of vascular endothelial growth factor receptor-2 to the activation of phosphoinositide 3-kinase.Semantic proximity Read ↗

The multi-site docking protein Gab1 is constitutively phosphorylated independent from its recruitment to the plasma membrane in Jak2-V617F-positive cells and mediates proliferation of human erythroleukaemia cells.Semantic proximity Read ↗

Membrane targeting of Grb2-associated binder-1 (Gab1) scaffolding protein through Src myristoylation sequence substitutes for Gab1 pleckstrin homology domain and switches an epidermal growth factor response to an invasive morphogenic program.Semantic proximity Read ↗

Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2.Semantic proximity Read ↗

Gab2 Is Involved in Differential Phosphoinositide 3-Kinase Signaling by Two Splice Forms of c-KitSemantic proximity Read ↗

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