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Article

Gab2 regulates cytoskeletal organization and migration of mammary epithelial cells by modulating RhoA activation.

Molecular biology of the cell - 1 Jan 2011

Herrera Abreu Maria Teresa, Hughes William E, Mele Katarina, Lyons Ruth J, Rickwood Danny, Browne Brigid C, Bennett Haley L, Vallotton Pascal, Brummer Tilman, Daly Roger J

Abstract excerpt

The docking protein Gab2 is overexpressed in several human malignancies, including breast cancer, and is associated with increased metastatic potential. Here we report that Gab2 overexpression in MCF-10A mammary epithelial cells led to delayed cell spreading, a decrease in stress fibers and matur...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21118992
DOI: 10.1091/mbc.E10-03-0185
PMCID: PMC3016968

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21118992-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Gab2 regulates cytoskeletal organization and migration of mammary epithelial cells by modulating RhoA activation.PMID 21118992Read ↗

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