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Article

An adenosyl-cobalamin (coenzyme-B12)-repressed translational enhancer in the cob mRNA of Salmonella typhimurium.

Molecular microbiology - 1 Mar 2001

Ravnum S, Andersson D I

Abstract excerpt

Expression of the cobalamin (Cbl) biosynthetic cob operon in Salmonella typhimurium is repressed by the end-product. This regulation is conferred mainly at the translational level and involves a cobalamin-induced folding of an RNA hairpin that sequesters the ribosomal binding site (RBS) of the cob mRNA and prevents translation initiation. A combined structural and mutational analysis shows that a cis-acting...

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PMID: 11260475
DOI: 10.1046/j.1365-2958.2001.02346.x

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