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Article

Human Fibroblast Commitment to a Senescence-Like State in Response to Histone Deacetylase Inhibitors Is Cell Cycle Dependent

1 Sept 1996

Abstract excerpt

Human diploid fibroblasts (HDF) complete a limited number of cell divisions before entering a growth arrest state that is termed replicative senescence. Two histone deacetylase inhibitors, sodium butyrate and trichostatin A, dramatically reduce the HDF proliferative life span in a manner that is dependent on one or more cell doublings in the presence of these agents. Cells arrested and subsequently released from...

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Share to Advanced biosensing and bioanalysis techniques
Share to Genomics and Chromatin Dynamics
Share to Telomeres, Telomerase, and Senescence

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Identifiers

PMID: 8756678
DOI: 10.1128/mcb.16.9.5210

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