Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A role for chemokine receptor transactivation in growth factor signaling.

EMBO reports - 1 Feb 2001

Mira E, Lacalle R A, González M A, Gómez-Moutón C, Abad J L, Bernad A, Martínez-A C, Mañes S

Abstract excerpt

Complex cell responses require the integration of signals delivered through different pathways. We show that insulin-like growth factor (IGF)-I induces specific transactivation of the Gi-coupled chemokine receptor CCR5, triggering its tyrosine phosphorylation and Galpha recruitment. This transact...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Polarity
Share to Chemokine CCL5
Share to Chemotaxis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP-Binding Protein alpha Subunits, Gi-Go

Share to Insulin-Like Growth Factor I

Share to Oligopeptides

Share to Protein Sorting Signals

Share to Receptors, CCR5

Source

Open in PubMed Open full text

Identifiers

PMID: 11258708
DOI: 10.1093/embo-reports/kve027
PMCID: PMC1083823

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11258708-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A role for chemokine receptor transactivation in growth factor signaling.PMID 11258708Read ↗

The receptor for the type I insulin-like growth factor and its ligands regulate multiple cellular functions that impact on metastasis.Semantic proximity Read ↗

The Role of the IGF System in Cancer Growth and Metastasis: Overview and Recent InsightsSemantic proximity Read ↗

Regulation of MAPKs by growth factors and receptor tyrosine kinases.Semantic proximity Read ↗

EGFR signal transactivation in cancer cellsSemantic proximity Read ↗

Insulin-like growth factors control cell migration in health and diseaseSemantic proximity Read ↗

Mechanisms regulating chemokine receptor activitySemantic proximity Read ↗

Separate elements are required for ligand-dependent and -independent internalization of metastatic potentiator CXCR4.Semantic proximity Read ↗

The GS Domain of the Transforming Growth Factor-β Type-I Receptor Is Important in Signal TransductionSemantic proximity Read ↗

Stimulatory actions of IGF-I are mediated by IGF-IR cross-talk with GPER and DDR1 in mesothelioma and lung cancer cellsSemantic proximity Read ↗

Multiple pathways contribute to the hyperproliferative responses from truncated granulocyte colony-stimulating factor receptors.Semantic proximity Read ↗

Noncanonical roles of chemokine regions in CCR9 activation revealed by structural modeling and mutational mappingSemantic proximity Read ↗

The IGF-I receptor in cell growth, transformation and apoptosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.