Article
To charge or not to charge?
Trends in biotechnology - 1 Apr 2001
Sanchez-Ruiz J M, Makhatadze G I
Abstract excerpt
The ability to engineer proteins with increased thermostability will profoundly broaden their practical applications. Recent experimental results show that optimization of charge-charge interactions on the surface of proteins can be a useful strategy in the design of thermostable enzymes. Results also indicate a possibility that such optimized interactions provide structural determinants for enhanced stability of...
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