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Article

Protein thermostabilization requires a fine-tuned placement of surface-charged residues.

Journal of biochemistry - 1 Oct 2007

You Dong-Ju, Fukuchi Satoshi, Nishikawa Ken, Koga Yuichi, Takano Kazufumi, Kanaya Shigenori

Abstract excerpt

Using the information from the genome projects, recent comparative studies of thermostable proteins have revealed a certain trend of amino acid composition in which polar residues are scarce and charged residues are rich on the protein surface. To clarify experimentally the effect of the amino acid composition of surface residues on the thermostability of Escherichia coli Ribonuclease HI (RNase HI), we...

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Identifiers

PMID: 17761696
DOI: 10.1093/jb/mvm157

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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