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Article

A simple electrostatic criterion for predicting the thermal stability of proteins.

Protein engineering - 1 Apr 2003

Mozo-Villarías Angel, Cedano Juan, Querol Enrique

Abstract excerpt

The enhancement of protein thermostability is an important issue for both basic science and biotechnology purposes. We have developed a thermostability criterion for a protein in terms of a quasi-electric dipole moment (contributed by its charged residues) defined for an electric charge distribution whose total charge is not zero. It was found that minimization of the modulus of this dipole moment increased its...

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PMID: 12736371
DOI: 10.1093/proeng/gzg033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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