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Article

Effects of charge-to-alanine substitutions on the stability of ribosomal protein L30e from Thermococcus celer.

Biochemistry - 27 Dec 2005

Lee Chi-Fung, Makhatadze George I, Wong Kam-Bo

Abstract excerpt

The ability to rationally engineer a protein with altered stability depends upon the detailed understanding of the role of noncovalent interactions in defining thermodynamic properties of proteins. In this paper, we used T. celer L30e as a model to address the question of the role of charge-charge interactions in defining the stability of this protein. A total of 26 single-site charge-to-alanine variants of this...

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PMID: 16363795
DOI: 10.1021/bi0519654

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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