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Generation of human high‐affinity antibodies specific for the fibroblast activation protein by guided selection

15 Mar 2001

Abstract excerpt

Four completely human antibody derivatives [single-chain-antibody fragments (scFvs)] with specificity for the general tumor stroma marker fibroblast activation protein (FAP) were isolated by guided selection. Highly diverse IgG, IgM and IgD isotypes comprising heavy-chain variable domain libraries were generated using cDNAs derived from diverse lymphoid organs of a multitude of donors. Three of the human scFvs...

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PMID: 11248693
DOI: 10.1046/j.1432-1327.2001.02046.x

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