Article
Renal medullary gene expression in aquaporin-1 null mice.
American journal of physiology. Renal physiology - 1 Feb 2005
McReynolds Matthew R, Taylor-Garcia Katherine M, Greer Kevin A, Hoying James B, Brooks Heddwen L
Abstract excerpt
Mice that lack the aquaporin-1 gene (AQP1) lack a functional countercurrent multiplier mechanism, fail to concentrate the inner medullary (IM) interstitium, and present with a urinary concentrating defect. In this study, we use DNA microarrays to identify the gene expression profile of the IM of AQP1 null mice and corresponding changes in gene expression resulting from a loss of a hypertonic medullary...
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