Article
Invasiveness of cutaneous malignant melanoma is influenced by matrix metalloproteinase 1 gene polymorphism.
Cancer research - 15 Feb 2001
Ye S, Dhillon S, Turner S J, Bateman A C, Theaker J M, Pickering R M, Day I, Howell W M
Abstract excerpt
The matrix metalloproteinases (MMPs) are implicated in connective tissue destruction during cancer invasion and metastasis. A naturally occurring variant arising from the insertion or deletion of a guanine in the promoter of the MMP-1 gene has recently been reported and shown to influence its transcriptional activity in melanoma cells. In this study, MMP-1 genotype was determined in 139 Caucasian patients with...
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