Article
The Bacteriophage T4 MotB Protein, a DNA-Binding Protein, Improves Phage Fitness.
Viruses - 26 Jun 2018
Patterson-West Jennifer, Arroyo-Mendoza Melissa, Hsieh Meng-Lun, Harrison Danielle, Walker Morgan M, Knipling Leslie, Hinton Deborah M
Abstract excerpt
The lytic bacteriophage T4 employs multiple phage-encoded early proteins to takeover the Escherichia coli host. However, the functions of many of these proteins are not known. In this study, we have characterized the T4 early gene motB, located in a dispensable region of the T4 genome. We show that heterologous production of MotB is highly toxic to E. coli, resulting in cell death or growth arrest depending on...
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