Article
CEBPA polymorphisms and mutations in patients with acute myeloid leukemia, myelodysplastic syndrome, multiple myeloma and non-Hodgkin's lymphoma.
Blood cells, molecules & diseases - 1 Jan 2000
Fuchs Ota, Provaznikova Dana, Kocova Marcela, Kostecka Arnost, Cvekova Pavla, Neuwirtova Radana, Kobylka Petr, Cermak Jaroslav, Brezinova Jana, Schwarz Jiri, Markova Jana, Salaj Peter, Klamova Hana, Maaloufova Jacqueline, Lemez Petr, Novakova Ludmila, Benesova Katerina
Abstract excerpt
The transcription factor CCAAT/enhancer binding protein (C/EBP)alpha is a myeloid-specific transcription factor which is required for normal myeloid differentiation. C/EBPalpha is encoded by an intronless gene that is 2783 bp long and maps to human chromosome 19q13.1. C/EBPalpha is a member of the basic region leucine zipper (bZIP) class of DNA-binding proteins. The loss of function of C/EBPalpha has leukemogenic...
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